GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2275426 | 1 | rs7556615 | chr1:46461369 | CCDC163P | chr1:45960581-45965646:- | -0.34 | -6.43 | 3.87E-10 | Body mass index |
| BLCA | cis | rs9309473 | 1 | rs7558944 | chr2:73810909 | ALMS1P | chr2:73872046-73912692:+ | 0.36 | 5.22 | 2.93E-7 | Metabolite levels |
| BLCA | cis | rs4075511 | 1 | rs7560267 | chr2:18239971 | KCNS3 | chr2:18059114-18114224:+ | 0.26 | 4.26 | 2.52E-5 | Temperament (bipolar disorder) |
| BLCA | cis | rs12618769 | 1 | rs7560357 | chr2:99247820 | REV1 | chr2:100016939-100106480:- | 0.27 | 4.34 | 1.81E-5 | Bipolar disorder |
| BLCA | cis | rs12618769 | 1 | rs7560357 | chr2:99247820 | UNC50 | chr2:99225042-99234975:+ | 0.39 | 5.29 | 2.1E-7 | Bipolar disorder |
| BLCA | cis | rs4372836 | 1 | rs7562170 | chr2:28943516 | TRMT61B | chr2:29072690-29093175:- | 0.29 | 5.11 | 5.05E-7 | Body mass index |
| BLCA | cis | rs9309473 | 1 | rs7564890 | chr2:73641853 | ALMS1P | chr2:73872046-73912692:+ | 0.35 | 5.07 | 6.32E-7 | Metabolite levels |
| BLCA | cis | rs60843830 | 1 | rs7566279 | chr2:281178 | SH3YL1 | chr2:218138-264810:- | -0.46 | -12.05 | 1.47E-28 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs9309473 | 1 | rs7572722 | chr2:73724675 | ALMS1P | chr2:73872046-73912692:+ | 0.33 | 4.85 | 1.79E-6 | Metabolite levels |
| BLCA | cis | rs882367 | 1 | rs757608 | chr17:59497277 | C17orf82 | chr17:59489112-59490641:+ | 0.19 | 4.18 | 3.67E-5 | Sitting height ratio |
| BLCA | cis | rs9309473 | 1 | rs7576245 | chr2:73829678 | ALMS1P | chr2:73872046-73912692:+ | 0.38 | 5.68 | 2.68E-8 | Metabolite levels |
| BLCA | cis | rs7714584 | 1 | rs75774363 | chr5:150223722 | LOC134466 | chr5:150310000-150326146:- | 0.46 | 5.54 | 5.76E-8 | Crohn's disease |
| BLCA | cis | rs4372836 | 1 | rs7579277 | chr2:28996295 | TRMT61B | chr2:29072690-29093175:- | -0.33 | -5.86 | 1.02E-8 | Body mass index |
| BLCA | cis | rs67073037 | 1 | rs7580240 | chr2:29114372 | TRMT61B | chr2:29072690-29093175:- | 0.31 | 4.78 | 2.56E-6 | Breast cancer (estrogen-receptor negative);Breast cancer |
| BLCA | cis | rs9309473 | 1 | rs7580825 | chr2:73635148 | ALMS1P | chr2:73872046-73912692:+ | 0.33 | 4.83 | 1.94E-6 | Metabolite levels |